the anti-inflammatory and anti-apoptotic effects of gallic acid against mucosal inflammation- and erosions-induced by gastric ischemia-reperfusion in rats

نویسندگان

seyyed ali mard

shahnaz mojadami

yaghoob farbood

mohammad kazem gharib naseri

چکیده

the present study aimed to evaluate the protective effect of gallic acid on gastric mucosal lesions caused by ischemia-reperfusion (i/r) injury in rat. forty male rats were randomly divided into sham, control (i/r injury) and three gallic acid-pretreated groups. to induce i/r lesions, the celiac artery was clamped for 30 min and then the clamp was removed to allow reperfusion for 6 hr. pretreated rats received gallic acid (15, 30 or 60 mg kg-1, intraperitoneally) 30 min prior to the induction of i/r injury. macroscopic and microscopic evaluations of the areas of ulceration were compared. samples of gastric mucosa were collected to evaluate the protein expression of pro-apoptotic factor, caspase-3, and pro-inflammatory enzyme, inducible nitric oxide synthase (inos) using western blot. pretreatment with gallic acid decreased the total area of gastric lesions. gallic acid at 30 mg kg-1 decreased the levels of protein expression of caspase-3 and inos induced by i/r injury. our findings showed the protective effect of gallic acid on gastric mucosa against ischemia-reperfusion injury. this effect of gallic acid was mainly mediated by reducing protein expression of inos and caspase-3.

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The anti-inflammatory and anti-apoptotic effects of gallic acid against mucosal inflammation- and erosions-induced by gastric ischemia-reperfusion in rats

The present study aimed to evaluate the protective effect of gallic acid on gastric mucosal lesions caused by ischemia-reperfusion (I/R) injury in rat. Forty male rats were randomly divided into sham, control (I/R injury) and three gallic acid-pretreated groups. To induce I/R lesions, the celiac artery was clamped for 30 min and then the clamp was removed to allow reperfusion for 6 hr. Pretreat...

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The anti-inflammatory and anti-apoptotic effects of gallic acid against mucosal inflammation- and erosions-induced by gastric ischemia-reperfusion in rats.

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عنوان ژورنال:
veterinary research forum

ناشر: faculty of veterinary medicine, urmia university

ISSN 2008-8140

دوره 6

شماره 4 2015

کلمات کلیدی
[ ' c a s p a s e ' , 3 , ' g a l l i c a c i d ' , ' i n d u c i b l e n i t r i c o x i d e s y n t h a s e ' , ' i s c h e m i a ' , ' r e p e r f u s i o n i n j u r y ' , ' r a t ' ]

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